Case Reports in Critical Care

Case Report

Simultaneous, Dual Continuous Venovenous Haemodiafiltration as Salvage Therapy for Severe Sodium Valproate Intoxication

Table 1

Serum VPA level on admission then after clearance with continuous venovenous haemodiafiltration (CVVHDF). The initial 24 hours of treatment was with single-filter CVVHDF. At 48 hours, there had been 22 hours of dual-filter CVVHDF following an initial 26 hours of single-filter CVVHDF. Finally, dual filtration was stepped down to single filtration after 31 hours. Single-filter CVVHDF was continued for a further 20 hours.
Serum VPA level (μg/ml)
On admission975
After CVVHDF treatment
 24 hrs82
 48 hrs23
 77 hrs<13