Research Article

Improving Cutaneous Wound Healing in Diabetic Mice Using Naturally Derived Tissue-Engineered Biological Dressings Produced under Serum-Free Conditions

Figure 7

ASC-based biological dressings display a pro-angiogenic secretion profile. Quantification by ELISA of secreted levels of HGF, PAI-1, VEGF, Ang-1, and bFGF in media conditioned for 48 hr in vitro by the dressings. Each colored dot represents the mean values obtained for different donors. N = 3 ASC populations, n = 3–4 tissues per population per time-point. Of note, for bFGF at D35, the levels measured in the conditioned media were below the threshold control levels for two of the three ASC populations analyzed at the time-point. Mean ± SD, one-way ANOVA with Tukey’s post-hoc test. No statistically significant differences were observed between the three time-points for all tested molecules.